Deep Dive Article

The AI Peptide Pipeline

How generative design, digital twins and human trials fit together, and where the shortcut stops.

Before You Buy a Biological Age Test

What the number means, why it can move, and when it should change a decision.

The Peptides Aimed at Ageing Itself

Five compounds, five different ways the evidence gives way — and three rules you can take to any peptide claim you meet next.

Twenty-One Peptides, Graded

From tirzepatide to epitalon — one A-to-F scale, applied to the compounds an FDA panel has just voted to bring within reach.

The statin threshold just dropped 🧬

A 66-item side-effect list that shrank to four, and a supplement the EU just voted to ban.

Five Drugs, One Lever - What it means for the shopping decision

Statins, ezetimibe, bempedoic acid and a fermented rice — four routes to one receptor, and why your arteries can't tell which one you took

Your Test Weighs the Cargo. The Damage Is Done by the Lorries

One protein per particle, millions of particles, and the reason lifetime exposure beats any number you can measure on a Tuesday morning

Fitness as a target, the four-minute interval that moves it, and why Zone 2 gets downgraded

13% - That's how much lower the risk of dying ran for each single MET of extra fitness, across 33 studies and more than 100,000 people. A MET is your whole resting metabolism.

Everyone Did the Same Fitness Training. The Results Weren't Even Close

Four hundred and eighty-one people, one supervised twenty-week programme, and a spread in results that launched thirty years of argument about whether "non-responder" is a real thing.

The Vital Sign Nobody Measures

Grip strength predicts death more sharply than blood pressure — but whether you can build your way out of the risk is a harder, more interesting question than the headline admits.

How Twelve People Made a Very Big Claim

An 83% drop in inflammation from twelve participants isn't stronger evidence than a 5% drop from five thousand — and the reason why will change how you read every supplement headline

Why the Mouse Lived Longer and You Probably Won't

A 12% lifespan gain in a lab mouse is thrilling, reproducible, and almost never transferable — and taurine is the newest name on a very long list.

Every Ashwagandha Trial Seems to Work. That's the Problem.

You're Probably Not Magnesium Deficient. You Might Still Be Short.

Around half of us eat too little magnesium — yet no ordinary blood test can tell you whether you're truly short. That gap, between intake and proof, is the whole business model.

The Vitamin D Trials Didn't Fail. They Tested the Wrong People.

Three giant trials, three null results — and why that's the most reassuring news in the field, not the most damning.

The Salt Argument Is Really an Argument About Who You Are

Two camps, both right about their own person and wrong to generalise. The methodology fight, the sweat-sodium maths, and a decision map you can actually find yourself on.

The Cold Plunge Works by Cancelling the Adaptation You Came For

Less soreness doesn't buy more growth — the trials already tested the objection everyone raises. Here's the answer, and the decision map by training goal

Bryan Johnson's Best Result Is the One He Doesn't Lead With

The DunedinPACE number is the headline. The bloods are the proof. Telling them apart is the whole game.

The Weight-Loss Drug That Cut Heart Attacks — and Failed at Alzheimer's

What "weight-independent benefit" actually means, and the honest line between treating ageing and treating the diseases it causes.

What the WHI Got Wrong

And what the November 2025 re-analysis still won't fix — including the "50% heart attack reduction" the headlines are now claiming.

When More Testosterone Made Bones Weaker

It is worth being precise about what the fracture finding does and doesn’t do.

Sauna Buys You Vascular Health — Not Fitness

Five trials in people who don't move at all, what they actually showed, and the only condition under which the wooden box does anything that resembles training.

The Grey Peptide Economy

How a $80 vial of BPC-157 leaves a Hebei industrial park and arrives in a Crouch End bathroom cabinet — and why the FDA crackdown didn't slow it down.

The Sleep Stage Ageing Takes First— and the Pill That Makes It Worse

Why the most restorative sleep stage quietly disappears, why the most-prescribed sleep drug accelerates the loss, and what the evidence says actually protects it.