Longevity

21 peptides graded. Only two got an A

The FDA's own scientists said no 🧬. Six of seven cleared a panel its own scientists opposed.

Twenty-One Peptides, Graded

From tirzepatide to epitalon — one A-to-F scale, applied to the compounds an FDA panel has just voted to bring within reach.

The statin threshold just dropped 🧬

A 66-item side-effect list that shrank to four, and a supplement the EU just voted to ban.

Five Drugs, One Lever - What it means for the shopping decision

Statins, ezetimibe, bempedoic acid and a fermented rice — four routes to one receptor, and why your arteries can't tell which one you took

Your blood test measured the wrong thing 🧬

The £0 number that beats the £299 panel. One free calculation you can do tonight, one test worth £30 if you're in the right group, and one you only ever need once.

Your Test Weighs the Cargo. The Damage Is Done by the Lorries

One protein per particle, millions of particles, and the reason lifetime exposure beats any number you can measure on a Tuesday morning

Fitness as a target, the four-minute interval that moves it, and why Zone 2 gets downgraded

13% - That's how much lower the risk of dying ran for each single MET of extra fitness, across 33 studies and more than 100,000 people. A MET is your whole resting metabolism.

Everyone Did the Same Fitness Training. The Results Weren't Even Close

Four hundred and eighty-one people, one supervised twenty-week programme, and a spread in results that launched thirty years of argument about whether "non-responder" is a real thing.

The muscle no supplement can sell you 🧬

Lifting graded A, protein graded B, and the £37 powder most people don't need.

The Vital Sign Nobody Measures

Grip strength predicts death more sharply than blood pressure — but whether you can build your way out of the risk is a harder, more interesting question than the headline admits.

Anti-ageing trial with 12 people 🧬

How Twelve People Made a Very Big Claim

An 83% drop in inflammation from twelve participants isn't stronger evidence than a 5% drop from five thousand — and the reason why will change how you read every supplement headline

The anti-ageing molecule that wasn't 🧬

Taurine made mice live longer. And us? A 2023 headline, a 2025 reversal, and the one taurine claim that actually holds up.

Why the Mouse Lived Longer and You Probably Won't

A 12% lifespan gain in a lab mouse is thrilling, reproducible, and almost never transferable — and taurine is the newest name on a very long list.

The one stress supplement with real trials behind it — and the safety signal the gummies don't mention

Does ashwagandha actually work?

Every Ashwagandha Trial Seems to Work. That's the Problem.

Are you really magnesium deficient? 🧬 Most magnesium is bought on a hunch

Half of us eat too little — far fewer are truly short. Plus: which form to buy, and why the spray barely gets in.

You're Probably Not Magnesium Deficient. You Might Still Be Short.

Around half of us eat too little magnesium — yet no ordinary blood test can tell you whether you're truly short. That gap, between intake and proof, is the whole business model.

Who actually needs vitamin D? 🧬 Vitamin D keeps failing its big trials

VITAL and DO-HEALTH enrolled the wrong people. Plus: the one blood number — and why most of us shouldn't test it.

The Vitamin D Trials Didn't Fail. They Tested the Wrong People.

Three giant trials, three null results — and why that's the most reassuring news in the field, not the most damning.

You probably need less salt, not more 🧬

The £45 electrolyte habit, audited.The powder industry sells you sodium — the hard-outcome trials point the other way. Plus: is "structured" water anything?

The Salt Argument Is Really an Argument About Who You Are

Two camps, both right about their own person and wrong to generalise. The methodology fight, the sweat-sodium maths, and a decision map you can actually find yourself on.

Your ice bath is taxing your gains 🧬

The cold plunge fixes today, taxes tomorrow- Most plungers time the cold exactly wrong — and the £300 ring can't read inflammation.

The Cold Plunge Works by Cancelling the Adaptation You Came For

Less soreness doesn't buy more growth — the trials already tested the objection everyone raises. Here's the answer, and the decision map by training goal

The Blueprint Audit: What 70 Pills a Day Actually Buys

70 pills, three that earn their place - The famous ageing-clock number isn't the win — the boring biomarker underneath it is. We audited the stack. Read on