The Sleep Stage Ageing Takes First— and the Pill That Makes It Worse

Why the most restorative sleep stage quietly disappears, why the most-prescribed sleep drug accelerates the loss, and what the evidence says actually protects it.

Three brain supplements. One works

We graded Lion’s Mane, creatine, and phosphatidylserine. One is worth buying. The other two have better marketing than evidence. Plus: a £95/month nootropic subscription dismantled

Your gut is ageing faster than you think 🧬

Probiotics graded A–F. Berberine’s stunning 6-year data. A £300 test that can’t agree with itself. 🧬

What Centenarians’ Guts Look Like

And Why Yours Doesn’t Have to Be Different

Resveratrol: the $720M mistake 🧬

Curcumin, resveratrol, and sulforaphane graded. Fisetin as a senolytic. That viral “age reversal” study — busted. 🧬

Autophagy and the Science of Cellular Renewal

How your cells take out the rubbish — and what happens when they stop

Sirtuins and NAD+ Metabolism

The Repair Enzymes at the Heart of Longevity Science

Mitochondrial Function and Longevity: What the Evidence Actually Shows

Your cells’ power plants degrade with age. Here’s what the science says about slowing it down

Inflammageing: The Fire That Ages You

One of the central drivers of age-related disease. It’s fuelled by senescent cells secreting inflammatory signals

Your mitochondria are declining. Here’s what works

Omega-3s, CoQ10, and PQQ graded for mitochondrial function

Autophagy: your cells’ cleanup crew

Rapamycin, spermidine, and quercetin graded. Telomere pills debunked. Broccoli sprouts earn their hype. Plus: why your brain can only clean itself while you sleep.

NMN costs £150/month. This NAD+ booster costs £0.03/day 🧬

The £4/month pill outlasting your supplements 🧬

AMPK: The Master Switch of Metabolic Ageing

How one ancient enzyme connects exercise, fasting, and the most studied longevity drugs — and why more activation isn’t always better.