21 peptides graded. Only two got an A

The FDA's own scientists said no 🧬. Six of seven cleared a panel its own scientists opposed.

Twenty-One Peptides, Graded

From tirzepatide to epitalon — one A-to-F scale, applied to the compounds an FDA panel has just voted to bring within reach.

The statin threshold just dropped 🧬

A 66-item side-effect list that shrank to four, and a supplement the EU just voted to ban.

Five Drugs, One Lever - What it means for the shopping decision

Statins, ezetimibe, bempedoic acid and a fermented rice — four routes to one receptor, and why your arteries can't tell which one you took

Your blood test measured the wrong thing 🧬

The £0 number that beats the £299 panel. One free calculation you can do tonight, one test worth £30 if you're in the right group, and one you only ever need once.

Your Test Weighs the Cargo. The Damage Is Done by the Lorries

One protein per particle, millions of particles, and the reason lifetime exposure beats any number you can measure on a Tuesday morning

Fitness as a target, the four-minute interval that moves it, and why Zone 2 gets downgraded

13% - That's how much lower the risk of dying ran for each single MET of extra fitness, across 33 studies and more than 100,000 people. A MET is your whole resting metabolism.

Everyone Did the Same Fitness Training. The Results Weren't Even Close

Four hundred and eighty-one people, one supervised twenty-week programme, and a spread in results that launched thirty years of argument about whether "non-responder" is a real thing.

The muscle no supplement can sell you 🧬

Lifting graded A, protein graded B, and the £37 powder most people don't need.

The Vital Sign Nobody Measures

Grip strength predicts death more sharply than blood pressure — but whether you can build your way out of the risk is a harder, more interesting question than the headline admits.

Anti-ageing trial with 12 people 🧬

How Twelve People Made a Very Big Claim

An 83% drop in inflammation from twelve participants isn't stronger evidence than a 5% drop from five thousand — and the reason why will change how you read every supplement headline

What Centenarians’ Guts Look Like

And Why Yours Doesn’t Have to Be Different

Autophagy and the Science of Cellular Renewal

How your cells take out the rubbish — and what happens when they stop

Sirtuins and NAD+ Metabolism

The Repair Enzymes at the Heart of Longevity Science

Mitochondrial Function and Longevity: What the Evidence Actually Shows

Your cells’ power plants degrade with age. Here’s what the science says about slowing it down

Inflammageing: The Fire That Ages You

One of the central drivers of age-related disease. It’s fuelled by senescent cells secreting inflammatory signals

AMPK: The Master Switch of Metabolic Ageing

How one ancient enzyme connects exercise, fasting, and the most studied longevity drugs — and why more activation isn’t always better.